IL-23R Signaling Plays No Role in Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
Vitamin D signaling pathway plays an important role in the development of heart failure after myocardial infarction.
Accumulating evidence suggests that vitamin D deficiency plays a crucial role in heart failure. However, whether vitamin D signaling itself plays an important role in cardioprotection is poorly understood. In this study, we examined the mechanism of modulating vitamin D signaling on progression to heart failure after myocardial infarction (MI) in mice. Vitamin D signaling was activated by admin...
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Interleukin (IL)-23 mediated signal transduction represents a major molecular mechanism underlying the pathology of inflammatory bowel disease, Crohn's disease and ulcerative colitis. In addition, emerging evidence supports the role of IL-23-driven Th17 cells in inflammation. Components of the IL-23 signaling pathway, such as IL-23R, JAK2 and STAT3, have been characterized, but elements unique ...
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RATIONALE In response to injury, the rodent heart is capable of virtually full regeneration via cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished as early as 1 week postnatal and remains lost in adulthood. The mechanisms that dictate postinjury cardiomyocyte proliferation early in life remain unclear. OBJECTIVE To delineate the role of miR-34a, a re...
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wave myocardial infarction, no redistribution on stress 20TI test, and single-vessel disease (>70% stenosis) with persistent anterograde blood flow were randomized to percutaneous transluminal coronary artery angioplasty (PTCA) or conservative medical treatment. After 2 months of follow-up, mean coronary blood flow measured by Doppler catheter in the infarct-related artery was higher in the PIC...
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SUMMARY The purpose of this study is to compare the level of zinc, copper and the ratio of zinc to copper in serum of patients who are suffering from acute myocardial infarction with healthy men. In 10 ml blood samples from 45 men on the second day of myocardial infarction and 51 healthy men volunteers matched for age, serum zinc, copper, cholesterol and triglycerides were measured. Zinc and c...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-35188-8